Tuberculosis (TB) in children is a silent scourge: one child dies of tuberculosis every three minutes and more than half of all children with TB are never diagnosed. Taking the opportunity of a set of new recommendations by the World Health Organisation (WHO), MSF has launched a worldwide project aiming to increase the number of children diagnosed with TB as well as improve their treatment experience and prevent new cases. This unprecedented initiative called "TACTiC" for “Test, Avoid, Cure Tuberculosis in Children” will support projects in implementing these new recommendations in over a dozen countries in Africa and Asia. In addition, the project aims to contribute to knowledge-building through several multi-country studies on the validity and feasibility of the recommendations, while advocating for their widespread implementation and the development of better tools to diagnose TB in children.