Doctors Without Borders has provided COVID-19 support to the Buea Regional Hospital since 2020 to curb the spread of the virus. Since the second week of March 2021, the Southwest Region of Cameroon has been experiencing the 2nd wave of COVID-19, with 194 identified cases within a five-week period. In response to the increase of COVID-19 positive cases, Doctors Without Borders has constructed a semipermanent structure for COVID-19 testing, provided donations of a Treatment Center, provided medication & medical supplies for inpatient and outpatients, donated Household Hygiene Kits which included supplies such as buckets, detergent, and face mask for the COVID-19 affected households. From September to October 2021, Doctors Without Borders Mental Health team staff has provided mental health care to 282 patients and tested 1,301 persons for COVID-19. There have been, 221 positive cases, with 85 hospitalization, and 175 patients in the home-based care system, and 39 patients were referred from other health facilities in the Region.