This communications package from Khayelitsha delivers a strong impression of an innovative COVID-19 vaccination campaign in action, as it happens on the ground in one of South Africa’s most populous townships. HIV is one of several comorbidities that are associated with death from COVID-19, and South Africa grapples with the largest HIV epidemic in the world. In the spirit of the country’s one-stop-shop approach to HIV treatment and care, MSF in Khayelitsha has developed a programme that supports people with HIV to receive COVID-19 vaccination jabs on the same day as their routine clinic visit. Since early December 2021, the programme has supported jabs for more than 3000 at-risk individuals in 3 clinics. In parallel, MSF teams in Khayelitsha have been taking vaccination into the community. Our approach includes the running of pop-up vaccine sites in busy community locales, supported by dazzling mural artworks that speak directly to hard-to-reach groups to encourage them to get vaccinated, like males and young people. Thanks to this approach, an additional 18,000 Khayelitsha residents have received the vaccine.