On 8th of June 2021, Médecins Sans Frontières launched a Covid-19 vaccination campaign for people suffering extreme hardship in Paris and its suburbs. In cooperation with the Paris Regional Health Agency (Agence Régionale de Santé d’Ile-de-France), and at the request of associations, MSF teams have been providing assistance to people in emergency shelters, day centres and workers' hostels or living out on the street since. At the end of August, more than 9 000 dosis had been injected and 80% of the people who received a first dose of vaccination with MSF came back for the second one.

Since March 2020, Médecins Sans Frontières has been delivering emergency assistance to ensure that people living in very challenging conditions are provided access to testing, isolation and medical treatment during the coronavirus pandemic. The association also runs mobile clinics for people living on the street so that they can continue to have access to primary health care. Over 5,000 medical examinations have already been given to migrants and/or people who have nowhere to go.