Tuberculosis continues to kill more than 1 million people each year. That’s why we want to see a safe, effective, and affordable vaccine against tuberculosis which – when combined with sustained investment in preventive therapies, diagnostics, and effective treatment regimens – would be a significant step towards reducing global mortality due to tuberculosis. While there is a vaccine (BCG) that helps to protect young children from severe forms of tuberculosis, there is currently no approved vaccine that protects adults and adolescents, either before or after exposure to tuberculosis infection. However, with several vaccine candidates in clinical development showing some promising initial results, there may soon be a viable tuberculosis vaccine that everyone can benefit from.