Malaria remains the leading cause of illness in South Sudan and accounts for 50 per cent of deaths in the country according to WHO with cases increasing during the rainy season. Children under five are particularly vulnerable to severe malaria and related complications. National Ministry of Health data shows persistently high numbers with 3.6 million cases in 2022, 3.8 million in 2023, and 3.8 million in 2024, reflecting a consistently high transmission pattern.

To help protect children in Twic County, Warrap State, MSF and the Twic County Health Department completed the first round of a seasonal malaria chemoprevention (SMC) campaign from 23 to 29 June 2026. During the campaign, 24,498 children aged three to 59 months received preventive malaria treatment across 12 locations, including Majook Noon, Abin Dau, Aweng, Gomgoi, Wunrok, Wunrieng, and Panyok.

The campaign also integrated nutrition screening with more than 500 children identified and referred for treatment of moderate or severe malnutrition.