Karachi’s Machar Colony is a densely populated slum where roughly 150,000 people live in polluted, unsanitary conditions. Most lack access to clean water and waste disposal. Many people in Machar work in the fishing industry, and during the offseason (June and July) there is widespread unemployment. MSF opened a clinic in 2012 with a local partner, SINA Health, Education and Welfare Trust, providing basic and emergency healthcare, including outpatient consultations, triage, stabilisation and referrals for emergencies. Labour and delivery support for pregnant women as well as antenatal and postnatal services were also available. In 2017, MSF closed the stabilisation room that it had been running in the clinic in order to focus on its hepatitis C project. MSF has been running a hepatitis C treatment programme in Machar since April 2015, and is working to develop a simplified model of care to improve people’s access to better and more effective treatment for this disease. Hepatitis C is a viral infectious disease that primarily affects the liver, and it is a chronic problem in Pakistan with a particularly high prevalence in Machar Colony. If left untreated it can lead to cirrhosis, liver failure or liver cancer. MSF health promotion teams run hepatitis C health and hygiene education sessions for parents and children. And as the community learns more about MSF’s hepatitis C programme, demand for care is increasing.